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Novel Virus-Based Colorimetric Sensor Can Show True Colors of Airborne Threats

THUMBNAIL IMAGE_Novel Virus-Based Colorimetric Sensor

Scientists employ genetically engineered viruses to produce intuitive color-coded sensors for detecting airborne chemicals 

In an exciting new study, scientists at Gwangju Institute of Science and Technology in Korea use genetically engineered viruses to fabricate highly efficient colorimetric sensors, which indicate the presence of specific harmful substances through intuitive color changes. Their design holds a lot of promise for the easy detection of hazardous industrial chemicals and airborne environmental pollutants.

The ongoing COVID-19 pandemic has shown that the world needs technology that can quickly and accurately identify invisible dangers, including harmful substances or airborne environmental pollutants. Colorimetric sensors—devices that intuitively reveal information about their environment through color changes—are an attractive option in this regard. But, for more people to benefit from these sensors, they must be easy to produce at a large scale. This is a major limitation with currently available colorimetric sensors, which require complex structures with intricate fabrication procedures. Other problems with existing devices include slow response times and unsaturated colors.

Now in a new study published in Advanced Science, scientists at Gwangju Institute of Science and Technology, Korea, have attempted to tackle these limitations by developing a new type of colorimetric sensor made up of a thin layer of viruses called M13 bacteriophages. They used this type of virus because it can change its structure—and thus its optical properties—in response to changes in the surrounding environment, such as the presence of harmful compounds. Prof Young Min Song, who led the study, explains, “In our study, we introduced the M13 bacteriophage, which is a nanometer-sized filamentous virus, as a sensing layer owing to its volumetrically expanding properties.”

The scientists genetically engineered the M13 bacteriophages by combining them with a “highly lossy ultra-thin resonance promoter layer” (HLRP) as the substrate. Then, they maximized the resonance of the coating layer of the viruses by optimizing the substrate such that the bacteriophage became extremely sensitive toward specific airborne substances. This made it possible for the “viruses” to detect chemicals at very low concentrations—as low as tens of parts per billion. Prof Song explains the technique, “Specifically, through optimization of the virus layer deposition, the virus layer was coated with ultra-thin dimension, which enhanced the detection rate. The HLRP with resonance enhancement was applied to obtain a distinct color even with a nanometer-scale thickness change in the M13 bacteriophage virus layer. Consequently, the color change was maximized by optimized resonance conditions.”

The scientists tested the new sensor with environmental variables, like changes in humidity, and with compounds like volatile organic chemicals and endocrine disrupting chemicals. In both cases, changes in these stimuli could be successfully observed through distinct color changes in the sensor, thus showing its practical applicability.

This new design for highly effective and mass-producible colorimetric sensor holds much promise for a variety of real-life applications, such as detecting harmful industrial chemicals or assessing air quality. To top it all, these sensors could become invaluable tools in clinical settings, as Prof Song remarks, “In the future, advances in genetic engineering will enhance the sensitivity of the sensors and extend their applicability to the medical industry, where they could be used as diagnostic kits for detecting specific viruses and pathogens.”

With further research, this technology will hopefully work as a powerful means to show the true colors of invisible airborne threats.

Authors: Young Jin Yoo (1), Won-Geun Kim (2), Joo Hwan Ko (1), Yeong Jae Kim (1), Yujin Lee (2), Stefan G. Stanciu (3), Jong-Min Lee (4), Seungchul Kim (5), Jin-Woo Oh (2), and Young Min Song (1*)
Title of original paper: Large-Area Virus Coated Ultrathin Colorimetric Sensors with a Highly Lossy Resonant Promoter for Enhanced Chromaticity
Journal: Advanced Science
DOI: 10.1002/advs.202000978
(1) School of Electrical Engineering and Computer Science, Gwangju Institute of Science and Technology
(2) Department of Nano Fusion Technology, Pusan National University
(3) Center for Microscopy-Microanalysis and Information Processing, Politehnica University Bucharest
(4) Research Center for Energy Convergence and Technology, Pusan National University
(5) Department of Optics and Mechatronics Engineering, Pusan National University

*Corresponding authors’ emails: (Y. M. Song)

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